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Article

Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.

Molecular biology of the cell - 1 Apr 2006

McNeil Elizabeth, Capaldo Christopher T, Macara Ian G

Abstract excerpt

Zonula occludens (ZO)-1 was the first tight junction protein to be cloned and has been implicated as an important scaffold protein. It contains multiple domains that bind a diverse set of junction proteins. However, the molecular functions of ZO-1 and related proteins such as ZO-2 and ZO-3 have remained unclear. We now show that gene silencing of ZO-1 causes a delay of approximately 3 h in tight junction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16436508
DOI: 10.1091/mbc.e05-07-0650
PMCID: PMC1415307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.PMID 16436508Read ↗

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