Article
Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation.
Experimental cell research - 1 Nov 2008
Sheth Bhavwanti, Nowak Rachael L, Anderson Rebecca, Kwong Wing Yee, Papenbrock Thomas, Fleming Tom P
Abstract excerpt
Apicolateral tight junctions (TJs) between epithelial cells are multiprotein complexes regulating membrane polarity and paracellular transport and also contribute to signalling pathways affecting cell proliferation and gene expression. ZO-2 and other ZO family members form a sub-membranous scaffold for binding TJ constituents. We investigated ZO-2 contribution to TJ biogenesis and function during trophectoderm...
Topics
- Animals
- Blastocyst
- Blotting, Western
- Cell Differentiation
- Embryo Culture Techniques
- Embryonic Development
- Epithelial Cells
- Gene Expression Regulation, Developmental
- Membrane Proteins
- Mice
- Mutation
- Phosphoproteins
- RNA, Messenger