Article
Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile.
Development (Cambridge, England) - 1 Sept 1996
Rankin T, Familari M, Lee E, Ginsberg A, Dwyer N, Blanchette-Mackie J, Drago J, Westphal H, Dean J
Abstract excerpt
Mammalian oocytes synthesize and secrete a zona pellucida that surrounds the growing oocytes, ovulated eggs and preimplantation embryos. The extracellular zona matrix is composed of three glycoproteins (ZP1, ZP2, ZP3) that are involved in folliculogenesis, species-specific fertilization, and pass...
Topics
- Animals
- Blotting, Southern
- Egg Proteins
- Female
- Gene Targeting
- Genotype
- Homozygote
- Immunohistochemistry
- In Situ Hybridization
- Infertility, Female
- Male
- Membrane Glycoproteins
- Mice
- Mice, Transgenic
- Microscopy, Confocal
- Mutagenesis, Insertional
- Oocytes
- Ovary