Article
Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008
Jönsson Erik G, Larsson Kristina, Vares Maria, Hansen Thomas, Wang August G, Djurovic Srdjan, Rønningen Kjersti S, Andreassen Ole A, Agartz Ingrid, Werge Thomas, Terenius Lars, Hall Håkan
Abstract excerpt
Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia...
Topics
- Adult
- Aged
- Bipolar Disorder
- Case-Control Studies
- Cohort Studies
- Female
- Gene Frequency
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Meta-Analysis as Topic