Article
C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses.
Molecular psychiatry - 1 Sept 1998
Kunugi H, Fukuda R, Hattori M, Kato T, Tatsumi M, Sakai T, Hirose T, Nanko S
Abstract excerpt
A common missense mutation of the methylenetetrahydrofolate reductase (MTHFR) gene (C677T) has been shown to be a risk factor for premature cardiovascular disease and neural tube defect. Deficient activity of MTHFR has also been implicated in the pathogenesis of psychiatric conditions such as sch...
Topics
- Adult
- Age Factors
- Aged
- Alleles
- Bipolar Disorder
- Cytosine
- Depressive Disorder
- Gene Frequency
- Genotype
- Homozygote
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation, Missense
- Oxidoreductases Acting on CH-NH Group Donors
- Point Mutation
- Polymorphism, Genetic
- Psychotic Disorders