Article
Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia.
Brain research. Molecular brain research - 10 Sept 2003
Sazci Ali, Ergül Emel, Güzelhan Yalçin, Kaya Güner, Kara Ihsan
Abstract excerpt
To investigate the role of methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 130 schizophrenic patients and 226 controls, using a polymerase chain reaction restriction fragment length polymorphism method. The MTHFR T677 allele was significantly distributed (chi(2)=7.900; P=0.019), between schizophrenic cases and healthy controls. The...
Topics
- Alanine
- Alleles
- Chi-Square Distribution
- Cysteine
- DNA Mutational Analysis
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lymphocytes
- Methylenetetrahydrofolate Reductase (NADPH2)
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Schizophrenia
- Threonine