Article
Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
Brain, behavior, and immunity - 1 Nov 2011
Peerbooms Odette L J, van Os Jim, Drukker Marjan, Kenis Gunter, Hoogveld Loes, de Hert Marc, Delespaul Philippe, van Winkel Ruud, Rutten Bart P F
Abstract excerpt
Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation. We conducted a meta-analysis of all published case-control...
Topics
- Bipolar Disorder
- Confidence Intervals
- Data Interpretation, Statistical
- Depressive Disorder
- Epigenomics
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Linkage Disequilibrium
- Methylenetetrahydrofolate Reductase (NADPH2)
- Odds Ratio