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Article

Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.

American journal of epidemiology - 1 Jan 2007

Gilbody Simon, Lewis Sarah, Lightfoot Tracy

Abstract excerpt

The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, an...

Topics

Databases as Topic
Folic Acid
Genetic Variation
Humans
Mental Disorders
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Genetic
Risk Assessment
Risk Factors
United States

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17074966
DOI: 10.1093/aje/kwj347

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17074966-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.PMID 17074966Read ↗

C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies.Semantic proximity Read ↗

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Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar disorder: an updated meta-analysis.Semantic proximity Read ↗

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis.Semantic proximity Read ↗

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MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A ReviewSemantic proximity Read ↗

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