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Article

Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.

The American journal of tropical medicine and hygiene - 1 Dec 2007

Echeverry Diego F, Holmgren Gabrielle, Murillo Claribel, Higuita Juan C, Björkman Anders, Gil Jose P, Osorio Lyda

Abstract excerpt

The potential role of polymorphisms in the pfcrt and pfmdr1 genes and in vitro susceptibility to amodiaquine and desethylamodiaquine were explored in 15 chloroquine-resistant Colombian Plasmodium falciparum isolates. Single nucleotide polymorphisms in the pfcrt gene, including a newly reported mutation (S334N), were seen in isolates with decreased susceptibility to amodiaquine and desethylamodiaquine. The lowest...

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PMID: 18165517

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Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.PMID 18165517Read ↗

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