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Article

Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.

The American journal of tropical medicine and hygiene - 1 Dec 2007

Echeverry Diego F, Holmgren Gabrielle, Murillo Claribel, Higuita Juan C, Björkman Anders, Gil Jose P, Osorio Lyda

Abstract excerpt

The potential role of polymorphisms in the pfcrt and pfmdr1 genes and in vitro susceptibility to amodiaquine and desethylamodiaquine were explored in 15 chloroquine-resistant Colombian Plasmodium falciparum isolates. Single nucleotide polymorphisms in the pfcrt gene, including a newly reported mutation (S334N), were seen in isolates with decreased susceptibility to amodiaquine and desethylamodiaquine. The lowest...

Topics

Amino Acid Sequence
Amodiaquine
Animals
Antimalarials
Base Sequence
Colombia
Drug Resistance
Inhibitory Concentration 50
Membrane Transport Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multidrug Resistance-Associated Proteins

Parasitic Sensitivity Tests

Plasmodium falciparum

Polymorphism, Single Nucleotide

Protozoan Proteins

Source

Identifiers

PMID: 18165517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18165517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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