Article
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
The American journal of tropical medicine and hygiene - 1 Oct 2014
Venkatesan Meera, Gadalla Nahla B, Stepniewska Kasia, Dahal Prabin, Nsanzabana Christian, Moriera Clarissa, Price Ric N, Mårtensson Andreas, Rosenthal Philip J, Dorsey Grant, Sutherland Colin J, Guérin Philippe, Davis Timothy M E, Ménard Didier, Adam Ishag, Ademowo George, Arze Cesar, Baliraine Frederick N, Berens-Riha Nicole, Björkman Anders, Borrmann Steffen, Checchi Francesco, Desai Meghna, Dhorda Mehul, Djimdé Abdoulaye A, El-Sayed Badria B, Eshetu Teferi, Eyase Frederick, Falade Catherine, Faucher Jean-François, Fröberg Gabrielle, Grivoyannis Anastasia, Hamour Sally, Houzé Sandrine, Johnson Jacob, Kamugisha Erasmus, Kariuki Simon, Kiechel Jean-René, Kironde Fred, Kofoed Poul-Erik, LeBras Jacques, Malmberg Maja, Mwai Leah, Ngasala Billy, Nosten Francois, Nsobya Samuel L, Nzila Alexis, Oguike Mary, Otienoburu Sabina Dahlström, Ogutu Bernhards, Ouédraogo Jean-Bosco, Piola Patrice, Rombo Lars, Schramm Birgit, Somé A Fabrice, Thwing Julie, Ursing Johan, Wong Rina P M, Zeynudin Ahmed, Zongo Issaka, Plowe Christopher V, Sibley Carol Hopkins, Asaq Molecular Marker Study Group
Abstract excerpt
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to...
Topics
- Amino Acid Substitution