Article
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.
Antimicrobial agents and chemotherapy - 1 Dec 2014
Wurtz Nathalie, Fall Bécaye, Pascual Aurélie, Fall Mansour, Baret Eric, Camara Cheikhou, Nakoulima Aminata, Diatta Bakary, Fall Khadidiatou Ba, Mbaye Pape Saliou, Diémé Yaya, Bercion Raymond, Wade Boubacar, Pradines Bruno
Abstract excerpt
The involvement of Pfmdr1 (Plasmodium falciparum multidrug resistance 1) polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the association between polymorphisms in Pfmdr1 (N86Y, Y184F, S1034C, N1042D, and D1246Y) and Pfcrt (K76T) and in vitro responses to chloroqui...
Topics
- Adult
- Amodiaquine
- Antimalarials
- Artemisinins
- Biological Transport
- Child
- Chloroquine
- Drug Resistance
- Erythrocytes
- Ethanolamines
- Female
- Fluorenes
- Gene Expression
- Haplotypes