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Article

Analysis of polymorphisms in Plasmodium falciparum genes related to drug resistance: a survey over four decades under different treatment policies in Brazil.

Malaria journal - 19 Sept 2014

Inoue Juliana, Lopes Dinora, do Rosário Virgílio, Machado Marta, Hristov Angélica D, Lima Giselle Fmc, Costa-Nascimento Maria J, Segurado Aluísio C, Di Santi Silvia M

Abstract excerpt

BACKGROUND: Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS: Samples were collected on filter paper from patients infected in the Amazon region from 1984 to 2011. DNA was extracted with Chelex®...

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Identifiers

PMID: 25239550
DOI: 10.1186/1475-2875-13-372
PMCID: PMC4177603

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