Article
Analysis of polymorphisms in Plasmodium falciparum genes related to drug resistance: a survey over four decades under different treatment policies in Brazil.
Malaria journal - 19 Sept 2014
Inoue Juliana, Lopes Dinora, do Rosário Virgílio, Machado Marta, Hristov Angélica D, Lima Giselle Fmc, Costa-Nascimento Maria J, Segurado Aluísio C, Di Santi Silvia M
Abstract excerpt
BACKGROUND: Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS: Samples were collected on filter paper from patients infected in the Amazon region from 1984 to 2011. DNA was extracted with Chelex®...
Topics
- Antimalarials
- Brazil
- Drug Resistance
- Genetic Markers
- Genotype
- Humans
- Malaria, Falciparum
- Plasmodium falciparum
- Polymorphism, Single Nucleotide
- Protozoan Proteins