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Article

Increased pressure stimulates aberrant dendritic cell maturation.

Cellular & molecular biology letters - 1 Jan 2008

Craig David H, Schaubert Keri L, Shiratsuchi Hiroe, Kan-Mitchell June, Basson Marc D

Abstract excerpt

Patients with malignancy typically exhibit abnormal dendritic cell profiles. Interstitial tumor pressure is increased 20-50 mmHg over that in normal tissue. We hypothesized that elevated pressure in the tumor microenvironment may influence dendritic cell (DC) phenotype and function. Monocyte-derived immature and mature DC isolated from healthy human donors were exposed to either ambient or 40 mmHg increased...

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Identifiers

PMID: 18161009
DOI: 10.2478/s11658-007-0054-6
PMCID: PMC6275900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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