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Article

Human bronchial epithelium orchestrates dendritic cell activation in severe asthma

1 Mar 2017

Abstract excerpt

The innate immune response is impaired in asthma, with increased epithelial release of C-X-C motif chemokine ligand (CXCL)8, interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP). We hypothesised that dendritic cells might modulate the hyperresponsive epithelium in severe asthma. For this purpose, we investigated epithelial–dendritic crosstalk in normal and diseased conditions, and because ultrafine...

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PMID: 28275176
DOI: 10.1183/13993003.02399-2016

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