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Article

Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes

11 Mar 2020

Abstract excerpt

Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence of exogenous cytokines have been met with limited success. We hypothesized that DCs produced in a physiological manner may be more effective and found that platelets activate a cross-presentation program in peripheral blood...

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PMID: 32195350
DOI: 10.1126/sciadv.aaz1580

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