Article
Tumor-derived factors impaired motility and immune functions of dendritic cells through derangement of biophysical characteristics and reorganization of cytoskeleton.
Cell motility and the cytoskeleton - 1 Mar 2007
Zeng Zhu, Xu Xiaofeng, Zhang Yingyu, Xing Junjie, Long Jinhua, Gu Li, Wang Xianwei, Sun Dagong, Ka Weibo, Yao Weijuan, Wen Zongyao, Chien Shu
Abstract excerpt
The generation and progress of tumors are accompanied with a marked suppression of human immune system. To explore the mechanisms by which tumors escape from immune recognition, we studied the influences of tumor microenvironment on differentiation of dendritic cells (DCs), which play an important role in tumor immunology, by biophysical and immunological methods. It was found that the cytokines derived from...
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