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Article

Atmospheric pressure plasma-activated medium activates macrophages toward an antitumor M1 phenotype by modulating the SIRPα phagocytic checkpoint.

International immunopharmacology - 1 Aug 2026

Liu Jinren, Jiang Yifei, Zhong Linghui, Lu Jiajia, Li Rongrong, Pei Yifei, Tang Linyi, Sun Meng, Lv Meng, Shi Xingmin, Gong Fuliang, Wu Xili

Abstract excerpt

Macrophage-mediated tumor clearance is frequently restricted by the immunosuppressive tumor microenvironment. This study investigates the immunomodulatory effects of plasma-activated medium (PAM) on macrophage pro-inflammatory activation and antitumor function. Murine RAW264.7 and primary bone marrow-derived macrophages were treated with PAM generated by a helium atmospheric pressure plasma jet. Phenotypic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 42143502
DOI: 10.1016/j.intimp.2026.116865

Genes

PAM
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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