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Article

ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Feb 1999

Varon E, Janoir C, Kitzis M D, Gutmann L

Abstract excerpt

To evaluate the role of known topoisomerase IV and gyrase mutations in the fluoroquinolone (FQ) resistance of Streptococcus pneumoniae, we transformed susceptible strain R6 with PCR-generated fragments encompassing the quinolone resistance-determining regions (QRDRs) of parC or gyrA from different recently characterized FQ-resistant mutants. Considering the MICs of FQs and the GyrA and/or ParC mutations of the...

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Identifiers

PMID: 9925523
DOI: 10.1128/AAC.43.2.302
PMCID: PMC89068

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Source receipt: pubmed, retrieved 7 Sept 2026.

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ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae.PMID 9925523Read ↗

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