Article
ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Feb 1999
Varon E, Janoir C, Kitzis M D, Gutmann L
Abstract excerpt
To evaluate the role of known topoisomerase IV and gyrase mutations in the fluoroquinolone (FQ) resistance of Streptococcus pneumoniae, we transformed susceptible strain R6 with PCR-generated fragments encompassing the quinolone resistance-determining regions (QRDRs) of parC or gyrA from differen...
Topics
- Anti-Infective Agents
- Biological Transport
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Microbial Sensitivity Tests
- Mutation
- Streptococcus pneumoniae