Genetic and phenotypic variation of foot-and-mouth disease virus during serial passages in a natural host.

Abstract excerpt

Foot-and-mouth disease virus (FMDV), like other RNA viruses, exhibits high mutation rates during replication that have been suggested to be of adaptive value. However, even though genetic variation in RNA viruses and, more specifically, FMDV has been extensively examined during virus replication in a wide variety of in vitro cell cultures, very little is known regarding the generation and effects of genetic...

Topics

• Animals
• Cell Line
• Foot-and-Mouth Disease
• Foot-and-Mouth Disease Virus
• Genetic Variation
• Serial Passage
• Swine
• Virulence