Article
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.
DNA repair - 5 Dec 2002
Karanjawala Zarir E, Adachi Noritaka, Irvine Ryan A, Oh Eui K, Shibata Darryl, Schwarz Klaus, Hsieh Chih-Lin, Lieber Michael R
Abstract excerpt
There are two general pathways by which multicellular eukaryotes repair double-strand DNA breaks (DSB): homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). All mammalian mutants in the NHEJ pathway demonstrate a lack of B and T lymphocytes and ionizing radiation sensitivity. Among these NHEJ mutants, the DNA-PK(cs) and Artemis mutants are the least severe, having no obvious phenotype other...
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