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Article

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.

Nature structural & molecular biology - 1 Aug 2009

Rass Emilie, Grabarz Anastazja, Plo Isabelle, Gautier Jean, Bertrand Pascale, Lopez Bernard S

Abstract excerpt

Here we have used an intrachromosomal substrate to monitor the end joining of distant ends, which leads to DNA rearrangements in mammalian cells. We show that silencing Mre11 reduces the efficiency of nonhomologous end joining (NHEJ), affecting both the canonical and alternative pathways, partly in a manner that is independent of the ataxia-telangiectasia mutated kinase (ATM). Silencing of Rad50 or CtIP decreases...

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Identifiers

PMID: 19633668
DOI: 10.1038/nsmb.1641

Genes

ATM
MRE11
RAD50

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