Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.

The Journal of biological chemistry - 30 Oct 2009

Zhuang Jing, Jiang Guochun, Willers Henning, Xia Fen

Abstract excerpt

DNA double-stranded breaks (DSBs) are lethal if not repaired and are highly mutagenic if misrepaired. Nonhomologous end joining (NHEJ) is one of the major DSB repair pathways and can rejoin the DSB ends either precisely or with mistakes. Recent evidence suggests the existence of two NHEJ subpathways: conservative NHEJ (C-NHEJ), which does not require microhomology and can join ends precisely; and deletional NHEJ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA Breaks, Double-Stranded
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exonucleases

Share to Genomic Instability

Share to Methylation

Share to MRE11 Homologue Protein

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 19744924
DOI: 10.1074/jbc.M109.059444
PMCID: PMC2781611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.PMID 19744924Read ↗

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.Semantic proximity Read ↗

Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.Semantic proximity Read ↗

Repair of double-strand breaks by end joining.Semantic proximity Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read ↗

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining PathwaySemantic proximity Read ↗

A role for human homologous recombination factors in suppressing microhomology-mediated end joining.Semantic proximity Read ↗

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the StageSemantic proximity Read ↗

Human MRE11 is inactivated in mismatch repair‐deficient cancersSemantic proximity Read ↗

Analysis of NHEJ-Based DNA Repair after CRISPR-Mediated DNA Cleavage.Semantic proximity Read ↗

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joiningSemantic proximity Read ↗

Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication StressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.