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Article

Nonhomologous end joining and V(D)J recombination require an additional factor

25 Feb 2003

Abstract excerpt

DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in mammalian cells. It also functions to carry out rearrangements at the specialized breaks introduced during V(D)J recombination. Here, we describe a patient with T(-)B(-) severe combined immunodeficiency, whose cells have defects closely resembling those of NHEJ-defective rodent cells. Cells derived from this...

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PMID: 12604777
DOI: 10.1073/pnas.0437964100

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Source receipt: pubmed, retrieved 7 Sept 2026.

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