Article
Molecular structure of mutations at an autosomal locus in human cells: evidence for interallelic homologous recombination.
Annales de genetique - 1 Jan 1991
Little J B, Benjamin M B
Abstract excerpt
A high proportion of spontaneous mutations at the heterozygous thymidine kinase (TK) locus in a human B-lymphoblast cell line involved loss of the entire active allele. Loss of heterozygosity often extended to other loci on chromosome 17q. The authors have developed a system for analysing the role of homologous recombination and gene conversion in such events. A heteroallelic (TK-/-) cell line containing single +...
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