Interchromosomal gene conversion at an endogenous human cell locus.

doi:10.1093/genetics/158.2.757

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Article

Interchromosomal gene conversion at an endogenous human cell locus.

Genetics - 1 Jun 2001

Quintana P J, Neuwirth E A, Grosovsky A J

Abstract excerpt

To examine the relationship between gene conversion and reciprocal exchange at an endogenous chromosomal locus, we developed a reversion assay in a thymidine kinase deficient mutant, TX545, derived from the human lymphoblastoid cell line TK6. Selectable revertants of TX545 can be generated through interchromosomal gene conversion at the site of inactivating mutations on each tk allele or by reciprocal exchange...

Topics

Alleles
Cell Line
Crossing Over, Genetic
DNA, Complementary
Exons
Gene Conversion
Genetic Linkage
Genotype
Humans
Loss of Heterozygosity
Microsatellite Repeats
Models, Genetic
Mutation
Point Mutation
Polymorphism, Genetic
Recombination, Genetic
Thymidine Kinase

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Identifiers

PMID: 11404339
DOI: 10.1093/genetics/158.2.757
PMCID: PMC1461692

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