Article
The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae.
PLoS genetics - 10 Nov 2006
Lettier Gaëlle, Feng Qi, de Mayolo Adriana Antúnez, Erdeniz Naz, Reid Robert J D, Lisby Michael, Mortensen Uffe H, Rothstein Rodney
Abstract excerpt
Homologous recombination (HR) is a source of genomic instability and the loss of heterozygosity in mitotic cells. Since these events pose a severe health risk, it is important to understand the molecular events that cause spontaneous HR. In eukaryotes, high levels of HR are a normal feature of meiosis and result from the induction of a large number of DNA double-strand breaks (DSBs). By analogy, it is generally...
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