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Article

Deubiquitination of FANCD2 is required for DNA crosslink repair.

Molecular cell - 14 Dec 2007

Oestergaard Vibe H, Langevin Frederic, Kuiken Hendrik J, Pace Paul, Niedzwiedz Wojciech, Simpson Laura J, Ohzeki Mioko, Takata Minoru, Sale Julian E, Patel Ketan J

Abstract excerpt

Monoubiquitination of FANCD2 and PCNA promotes DNA repair. It causes chromatin accumulation of FANCD2 and facilitates PCNA's recruitment of translesion polymerases to stalled replication. USP1, a protease that removes monoubiquitin from FANCD2 and PCNA, was thought to reverse the DNA damage response of these substrates. We disrupted USP1 in chicken cells to dissect its role in a stable genetic system. USP1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18082605
DOI: 10.1016/j.molcel.2007.09.020
PMCID: PMC2148256

Genes

FANCD2
USP1
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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