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Article

The role of USP1 autocleavage in DNA interstrand crosslink repair.

FEBS letters - 1 Feb 2016

Kim Mira, Kim Jung Min

Abstract excerpt

The Fanconi anemia (FA) pathway regulates DNA interstrand crosslink (ICL) repair. A critical step in this pathway is mono-ubiquitination of FANCD2 (FANCD2-Ub). Deubiquitinase USP1 removes ubiquitin from FANCD2 resulting in inactivation of the FA pathway. USP1 is autocleaved and subsequently degraded for its down-regulation. Here, we investigated the functional consequences of Usp1-autocleavage defect....

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Source

Identifiers

PMID: 26783108
DOI: 10.1002/1873-3468.12060

Genes

FANCD2
USP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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