Article
Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.
Molecular and cellular biology - 1 Jan 2005
Yamamoto Kazuhiko, Hirano Seiki, Ishiai Masamichi, Morishima Kenichi, Kitao Hiroyuki, Namikoshi Keiko, Kimura Masayo, Matsushita Nobuko, Arakawa Hiroshi, Buerstedde Jean-Marie, Komatsu Kenshi, Thompson Larry H, Takata Minoru
Abstract excerpt
Recent studies show overlap between Fanconi anemia (FA) proteins and those involved in DNA repair mediated by homologous recombination (HR). However, the mechanism by which FA proteins affect HR is unclear. FA proteins (FancA/C/E/F/G/L) form a multiprotein complex, which is responsible for DNA damage-induced FancD2 monoubiquitination, a key event for cellular resistance to DNA damage. Here, we show that...
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