Article
The Fanconi anemia pathway: insights from somatic cell genetics using DT40 cell line.
Mutation research - 31 Jul 2009
Takata Minoru, Ishiai Masamichi, Kitao Hiroyuki
Abstract excerpt
The Fanconi anemia (FA) pathway is a complex phosphorylation-ubiquitination network in the DNA damage signaling, which is still poorly understood. Defects in the "FA pathway" or in the related DNA repair proteins cause FA, a hereditary disorder that accompanies compromised DNA crosslink repair, poor hematopoetic stem cell survival, genomic instability, and cancer. For molecular dissection of the FA pathway, we...
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