Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Molecular cell - 4 Feb 2005

Nijman Sebastian M B, Huang Tony T, Dirac Annette M G, Brummelkamp Thijn R, Kerkhoven Ron M, D'Andrea Alan D, Bernards René

Abstract excerpt

Protein ubiquitination and deubiquitination are dynamic processes implicated in the regulation of numerous cellular pathways. Monoubiquitination of the Fanconi anemia (FA) protein FANCD2 appears to be critical in the repair of DNA damage because many of the proteins that are mutated in FA are required for FANCD2 ubiquitination. By screening a gene family RNAi library, we identify the deubiquitinating enzyme USP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endopeptidases
Share to Fanconi Anemia
Share to Fanconi Anemia Complementation Group D2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Library

Share to Mitomycin

Share to Proteasome Endopeptidase Complex

Share to Ubiquitin

Share to Ubiquitin-Specific Proteases

Source

Identifiers

PMID: 15694335
DOI: 10.1016/j.molcel.2005.01.008

Genes

FANCD2
USP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.PMID 15694335Read ↗

Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.Semantic proximity Read ↗

The role of USP1 autocleavage in DNA interstrand crosslink repair.Semantic proximity Read ↗

Deubiquitination of FANCD2 is required for DNA crosslink repair.Semantic proximity Read ↗

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.Semantic proximity Read ↗

FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.Semantic proximity Read ↗

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.Semantic proximity Read ↗

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.Semantic proximity Read ↗

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.Semantic proximity Read ↗

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Semantic proximity Read ↗

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Semantic proximity Read ↗

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapySemantic proximity Read ↗

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.