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Article

BRCA1-independent ubiquitination of FANCD2.

Molecular cell - 1 Jul 2003

Vandenberg Cassandra J, Gergely Fanni, Ong Chong Yi, Pace Paul, Mallery Donna L, Hiom Kevin, Patel Ketan J

Abstract excerpt

Monoubiquitination of the FANCD2 protein is a key step in the Fanconi anemia (FA) tumor suppressor pathway, coinciding with this molecule's accumulation at sites of genome damage. Strong circumstantial evidence points to a requirement for the BRCA1 gene product in this step. Here, we show that the purified BRCA1/BARD1 complex, together with E1 and UbcH5a, is sufficient to reconstitute the monoubiquitination of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group D2 Protein

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Source

Identifiers

PMID: 12887909
DOI: 10.1016/s1097-2765(03)00281-8

Genes

FANCD2
BRCA1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1-independent ubiquitination of FANCD2.PMID 12887909Read ↗

Deubiquitination of FANCD2 is required for DNA crosslink repair.Semantic proximity Read ↗

A requirement of FancL and FancD2 monoubiquitination in DNA repair.Semantic proximity Read ↗

The Genetic and Biochemical Basis of FANCD2 MonoubiquitinationSemantic proximity Read ↗

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.Semantic proximity Read ↗

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.Semantic proximity Read ↗

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.Semantic proximity Read ↗

Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.Semantic proximity Read ↗

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.Semantic proximity Read ↗

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Semantic proximity Read ↗

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links.Semantic proximity Read ↗

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand crosslinksSemantic proximity Read ↗

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.Semantic proximity Read ↗

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