Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

1 Jun 2014

Abstract excerpt

Fanconi anaemia (FA) is a cancer predisposition syndrome characterized by cellular sensitivity to DNA interstrand crosslinkers. The molecular defect in FA is an impaired DNA repair pathway. The critical event in activating this pathway is monoubiquitination of FANCD2. In vivo, a multisubunit FA core complex catalyzes this step, but its mechanism is unclear. Here, we report purification of a native avian FA core...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24905007
DOI: 10.1016/j.molcel.2014.05.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Genetic and Biochemical Basis of FANCD2 MonoubiquitinationPMID 24905007Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

A requirement of FancL and FancD2 monoubiquitination in DNA repair.Semantic proximity Read ↗

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.Semantic proximity Read ↗

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing.Semantic proximity Read ↗

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.Semantic proximity Read ↗

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.Semantic proximity Read ↗

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Semantic proximity Read ↗

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair PathwaySemantic proximity Read ↗

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.Semantic proximity Read ↗

The Fanconi Anemia Pathway of Genomic MaintenanceSemantic proximity Read ↗

Insights into Fanconi Anaemia from the structure of human FANCE.Semantic proximity Read ↗

Fanconi anaemia and cancer: an intricate relationship.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.