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Article

FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.

Molecular cell - 27 Jun 2013

Park Eunmi, Kim Hyungjin, Kim Jung Min, Primack Benjamin, Vidal-Cardenas Sofia, Xu Ye, Price Brendan D, Mills Alea A, D'Andrea Alan D

Abstract excerpt

Fanconi anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most FA patients are deficient in this step. How monoubiquitinated FANCD2 suppresses squamous cell cancers is unknown. Here...

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Source

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Identifiers

PMID: 23806336
DOI: 10.1016/j.molcel.2013.05.017
PMCID: PMC3897475

Genes

FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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