Article
Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma.
Blood - 1 Apr 2008
Cozen Wendy, Gill Parkash S, Salam Muhammad T, Nieters Alexandra, Masood Rizwan, Cockburn Myles G, Gauderman W James, Martínez-Maza Otoniel, Nathwani Bharat N, Pike Malcolm C, Van Den Berg David J, Hamilton Ann S, Deapen Dennis M, Mack Thomas M
Abstract excerpt
Young adult Hodgkin lymphoma (YAHL) is associated clinically with altered immunity, including a systemic defect in cell-mediated responses. There is strong evidence of a genetic contribution to risk, so we hypothesized that heritable alterations in cytokine production associated with Th1 function may contribute to susceptibility. We identified twin pairs in whom at least one member had YAHL and measured...
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