Article
Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies.
British journal of haematology - 1 May 2011
Lan Qing, Wang Sophia S, Menashe Idan, Armstrong Bruce, Zhang Yawei, Hartge Patricia, Purdue Mark P, Holford Theodore R, Morton Lindsay M, Kricker Anne, Cerhan James R, Grulich Andrew, Cozen Wendy, Zahm Shelia H, Yeager Meredith, Vajdic Claire M, Schenk Maryjean, Leaderer Brian, Yuenger Jeff, Severson Richard K, Chatterjee Nilanjan, Chanock Stephen J, Zheng Tongzhang, Rothman Nathaniel
Abstract excerpt
The balance between T-helper 1 (Th1) and T-helper 2 (Th2) activity is critical in lymphoid cell development and differentiation. Immune dysfunction underlies lymphomagenesis, so an alteration in the regulation of key Th1/Th2 cytokines may lead to the development of non-Hodgkin lymphoma (NHL). To study the impact of polymorphisms in Th1/Th2 cytokines on NHL risk, we analyzed 145 tag single nucleotide polymorphisms...
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