Article
Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes.
Molecular carcinogenesis - 1 Jan 2011
Monroy Claudia M, Cortes Andrea C, Lopez Mirtha S, D'Amelio Anthony M, Etzel Carol J, Younes Anas, Strom Sara S, El-Zein Randa A
Abstract excerpt
Inflammation is a critical component of cancer development. The clinical and pathological features of Hodgkin disease (HD) reflect an abnormal immunity that results from cytokines secreted by Reed-Sternberg cells and the surrounding tumor. Numerous studies have reported the association between genetic polymorphisms in cytokine genes and the susceptibility to different hematologic cancers. However, the effects of...
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