Article
Polymorphism in cytokine genes as prognostic markers in Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2007
Hohaus S, Giachelia M, Di Febo A, Martini M, Massini G, Vannata B, D'Alo' F, Guidi F, Greco M, Pierconti F, Larocca L M, Voso M T, Leone G
Abstract excerpt
BACKGROUND: In Hodgkin's lymphoma (HL), the production of cytokines by Reed-Sternberg cells and the surrounding tissue is thought to contribute to the biology of the disease. Cytokine expression can be altered by common single nucleotide polymorphisms (SNPs) in the 5'-promoter regions. PATIENTS AND METHODS: We studied polymorphic allele variants of the cytokine genes interleukin (IL)-10 (T-3575A, G-2849A,...
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