Article
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007
Beroukhim Rameen, Getz Gad, Nghiemphu Leia, Barretina Jordi, Hsueh Teli, Linhart David, Vivanco Igor, Lee Jeffrey C, Huang Julie H, Alexander Sethu, Du Jinyan, Kau Tweeny, Thomas Roman K, Shah Kinjal, Soto Horacio, Perner Sven, Prensner John, Debiasi Ralph M, Demichelis Francesca, Hatton Charlie, Rubin Mark A, Garraway Levi A, Nelson Stan F, Liau Linda, Mischel Paul S, Cloughesy Tim F, Meyerson Matthew, Golub Todd A, Lander Eric S, Mellinghoff Ingo K, Sellers William R
Abstract excerpt
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze cancer genomes are underway, but the analysis is hampered by the lack of a statistical framework to distinguish meaningful events from random background aberrations. Here we describe a systematic method, called Genomic...
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