Article
Chromosome 22 tiling-path array-CGH analysis identifies germ-line- and tumor-specific aberrations in patients with glioblastoma multiforme.
Genes, chromosomes & cancer - 1 Oct 2005
Díaz de Ståhl Teresita, Hartmann Christian, de Bustos Cecilia, Piotrowski Arkadiusz, Benetkiewicz Magdalena, Mantripragada Kiran K, Tykwinski Tomasz, von Deimling Andreas, Dumanski Jan P
Abstract excerpt
Gliomas are common and frequently malignant tumors of the central nervous system. Recurrent allelic losses of chromosome 22 have been reported in gliomas, indicating tumor-suppressor genes at this location. However, the target genes are still unknown. We applied a high resolution tiling-path chromosome 22 array to a series of 50 glioblastoma samples, with the aim of investigating the underlying abnormalities in...
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