A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma

Abstract excerpt

A novel genome-wide screen that combines patient outcome analysis with array comparative genomic hybridization and mRNA expression profiling was developed to identify genes with copy number alterations, aberrant mRNA expression, and relevance to survival in glioblastoma. The method led to the discovery of physical gene clusters within the cancer genome with boundaries defined by physical proximity, correlated...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axon Guidance and Neuronal Signaling
• Share to Glioma Diagnosis and Treatment
• Share to Ubiquitin and proteasome pathways