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Article

Elevated signature of a gene module coexpressed with CDC20 marks genomic instability in glioma

15 Mar 2019

Abstract excerpt

Genomic instability (GI) drives tumor heterogeneity and promotes tumor progression and therapy resistance. However, causative factors underlying GI and means for clinical detection of GI in glioma are inadequately identified. We describe here that elevated expression of a gene module coexpressed with CDC20 (CDC20-M), the activator of the anaphase-promoting complex in the cell cycle, marks GI in glioma. The...

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PMID: 30877245
DOI: 10.1073/pnas.1814060116

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