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Article

Excess of homozygosity in the major histocompatibility complex in schizophrenia.

Human molecular genetics - 15 Nov 2014

Mukherjee Semanti, Guha Saurav, Ikeda Masashi, Iwata Nakao, Malhotra Anil K, Pe'er Itsik, Darvasi Ariel, Lencz Todd

Abstract excerpt

Genome-wide association studies (GWAS) in schizophrenia have focused on additive allelic effects to identify disease risk loci. In order to examine potential recessive effects, we applied a novel approach to identify regions of excess homozygosity in an ethnically homogenous cohort: 904 schizophrenia cases and 1640 controls drawn from the Ashkenazi Jewish (AJ) population. Genome-wide examination of runs of...

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Identifiers

PMID: 24943592
DOI: 10.1093/hmg/ddu308
PMCID: PMC4204767

Genes

TRIM10
TRIM15
TRIM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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