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Article

Schizophrenia: a common disease caused by multiple rare alleles.

The British journal of psychiatry : the journal of mental science - 1 Mar 2007

McClellan Jon M, Susser Ezra, King Mary-Claire

Abstract excerpt

Schizophrenia is widely held to stem from the combined effects of multiple common polymorphisms, each with a small impact on disease risk. We suggest an alternative view: that schizophrenia is highly heterogeneous genetically and that many predisposing mutations are highly penetrant and individually rare, even specific to single cases or families. This "common disease--rare alleles" hypothesis is supported by...

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Identifiers

PMID: 17329737
DOI: 10.1192/bjp.bp.106.025585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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