A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia.

doi:10.1093/schbul/sbaa161

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A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia.

Schizophrenia bulletin - 29 Apr 2021

Mahmood Tariq, El-Asrag Mohammed E, Poulter James A, Cardno Alastair G, Tomlinson Anneka, Ahmed Sophia, Al-Amri Ahmed, Nazari Jamshid, Neill Joanna, Chamali Rifka S, Kiwan Nancy, Ghuloum Suhaila, Alhaj Hamid A, Randerson Moor Juliette, Khan Shabana, Al-Amin Hassen, Johnson Colin A, Woodruff Peter, Wilkinson Iain D, Ali Manir, Clapcote Steven J, Inglehearn Chris F

Abstract excerpt

We report a consanguineous family in which schizophrenia segregates in a manner consistent with recessive inheritance of a rare, partial-penetrance susceptibility allele. From 4 marriages between 2 sets of siblings who are half first cousins, 6 offspring have diagnoses of psychotic disorder. Homozygosity mapping revealed a 6.1-Mb homozygous region on chromosome 13q22.2-31.1 shared by all affected individuals,...

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PMID: 33159203
DOI: 10.1093/schbul/sbaa161
PMCID: PMC8084434

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