Article
Interaction of RNA polymerase II fork loop 2 with downstream non-template DNA regulates transcription elongation.
The Journal of biological chemistry - 2 Sept 2011
Kireeva Maria L, Domecq Céline, Coulombe Benoit, Burton Zachary F, Kashlev Mikhail
Abstract excerpt
Fork loop 2 is a small semiconservative segment of the larger fork domain in the second largest Rpb2 subunit of RNA polymerase II (Pol II). This flexible loop, juxtaposed at the leading edge of transcription bubble, has been proposed to participate in DNA strand separation, translocation along DNA, and NTP loading to Pol II during elongation. Here we show that the Rpb2 mutant carrying a deletion of the flexible...
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