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Article

Correlation between Shiga toxin B-subunit stability and antigen crosspresentation: a mutational analysis.

FEBS letters - 23 Jan 2008

Pina David G, Stechmann Bahne, Shnyrov Valery L, Cabanié Lucien, Haicheur Nacilla, Tartour Eric, Johannes Ludger

Abstract excerpt

The homopentameric B-subunit of Shiga toxin (STxB) is used as a tool to deliver antigenic peptides and proteins to the cytosolic compartment of dendritic cells (DCs). In this study, a series of interface mutants of STxB has been constructed. All mutants retained their overall conformation, while a loss in thermal stability was observed. This effect was even more pronounced in trifluoroethanol solutions that mimic...

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Identifiers

PMID: 18070601
DOI: 10.1016/j.febslet.2007.11.086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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