Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Instability of toxin A subunit of AB(5) toxins in the bacterial periplasm caused by deficiency of their cognate B subunits.

Biochimica et biophysica acta - 1 Oct 2011

Kim Sang-Hyun, Ryu Su Hyang, Lee Sang-Ho, Lee Yong-Hoon, Lee Sang-Rae, Huh Jae-Won, Kim Sun-Uk, Kim Ekyune, Kim Sunghyun, Jon Sangyong, Bishop Russell E, Chang Kyu-Tae

Abstract excerpt

Shiga toxin (STx) belongs to the AB(5) toxin family and is transiently localized in the periplasm before secretion into the extracellular milieu. While producing outer membrane vesicles (OMVs) containing only A subunit of the toxin (STxA), we created specific STx1B- and STx2B-deficient mutants of E. coli O157:H7. Surprisingly, STxA subunit was absent in the OMVs and periplasm of the STxB-deficient mutants. In...

Topics

Bacterial Toxins
Base Sequence
DNA Primers
Genetic Complementation Test
Hydrolysis
Microscopy, Electron, Transmission
Mutation
Periplasm

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 21762677
DOI: 10.1016/j.bbamem.2011.06.016
PMCID: PMC5007120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Instability of toxin A subunit of AB(5) toxins in the bacterial periplasm caused by deficiency of their cognate B subunits.PMID 21762677Read ↗

Shiga toxin A subunit mutant of Escherichia coli O157:H7 releases outer membrane vesicles containing the B-pentameric complex.Semantic proximity Read ↗

A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid β by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit.Semantic proximity Read ↗

Targeting Type II Toxin–Antitoxin Systems as Antibacterial StrategiesSemantic proximity Read ↗

The serine 31 residue of the B subunit of Shiga toxin 2 is essential for secretion in enterohemorrhagic Escherichia coli.Semantic proximity Read ↗

Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7Semantic proximity Read ↗

Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C-terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer.Semantic proximity Read ↗

A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic <i>Escherichia coli </i>Semantic proximity Read ↗

Antiviral activity of shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells.Semantic proximity Read ↗

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin.Semantic proximity Read ↗

Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis.Semantic proximity Read ↗

Proteolytically Coordinated Activation of Toxin-Antitoxin ModulesSemantic proximity Read ↗

Characterization of heat-stable (STa) toxoids of enterotoxigenic Escherichia coli fused to double mutant heat-labile toxin peptide in inducing neutralizing Anti-STa antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.