Cryo‐ EM structures of engineered Shiga toxin‐based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against hemolytic uremic syndrome

Abstract excerpt

Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a serious disease that causes renal failure predominantly in children. Despite its significant impact, there are currently no licensed vaccines or effective therapies available. The B subunits of Shiga toxins 1 and 2 (Stx1B and Stx2B) are suitable targets for developing neutralizing antibodies, but their pentameric assembly...

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