Article
Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin.
Protein science : a publication of the Protein Society - 1 Feb 2013
Yumura Kyohei, Ui Mihoko, Doi Hirofumi, Hamakubo Takao, Kodama Tatsuhiko, Tsumoto Kouhei, Sugiyama Akira
Abstract excerpt
The defining property of core streptavidin (cSA) is not only its high binding affinity for biotin but also its pronounced thermal and chemical stability. Although potential applications of these properties including therapeutic methods have prompted much biological research, the high immunogenicity of this bacterial protein is a key obstacle to its clinical use. To this end, we have successfully constructed...
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